The solid-state NMR group is seeking applications for two ERC Advanced grant funded postdoctoral positions.
1) Postdoctoral Position in Development and Construction of MAS System for NMR Instrumentation (including Computational Fluid Dynamics)
The project is a collaboration with Prof. Jenny, Institute of Fluid Dynamics, and focusses on the development of innovative hardware for MAS (magic-angle spinning) NMR spectroscopy. Presently commercially accessible frequencies for MAS sample rotation, i.e. 110 kHz, are already faster than the ones of any other man-made object. Increasing the MAS frequency to 200-250 kHz will improve dramatically the spectral quality and allow solid-state NMR studies of large biological systems.
The successful candidate will work on the development and construction of a 200 kHz MAS probe. For the applications, she/he will collaborate with two postdocs/PhD students in the Meier’s group, which will also be hired within the same project. The RF-design and mechanical construction of the MAS probe will be done by the postdoc in collaboration with an electronic engineer with experience in probe design. The design and optimization of the rotation device include large-scale fluid-dynamic simulations in the group of Prof. Jenny. The postdoc will perform the characterization and empirical optimization of the hardware, according to weaknesses detected in experiments on biological systems.The successful candidate will be jointly supervised by Prof. Meier and Prof. Jenny.
Prerequisites are a Ph.D. in Physics, Interdisciplinary Sciences, Mechanical Engineering, Electrical Engineering, Biomedical Engineering, or related area, experience in application engineering of instrumentation, and finite element or finite volume simulations. Motivation to work in a multidisciplinary team and a strong interest in hardware development. Previous experience in solid-state NMR, Computational Fluid Dynamics (CFD) simulations and fluid dynamics measurements, or hardware development is an important asset. Starting date is upon mutual agreement.
More information about the ongoing projects in the solid-state NMR lab and the hardware available can be found at http://www.nmr.ethz.ch/, more information about the fluid dynamics group at http://www.ifd.mavt.ethz.ch/research/group-jenny.
2) Postdoctoral Position in NMR Methods Development for Fast MAS (>200 kHz)
The project will focus on the development of novel pulse sequences for fast MAS NMR spectroscopy. Increasing the presently accessible MAS frequencies (150 kHz) to 200-250 kHz will improve dramatically the spectral quality and allow solid-state NMR studies of large biological systems, e.g. amyloid fibrils, membrane proteins, virus capsids and proteins assemblies.
The successful candidate will work on the development of novel NMR pulse-sequences to be employed at such MAS frequencies. The theoretical and numerical spin-dynamics simulation work will be closely linked to experimental verification on model proteins and the candidate will collaborate with a postdoc developing the hardware. The experimental work of the candidate can be started with the equipment presently available in the lab at 110-140 kHz MAS. Magnets at 500, 600, 850 and, in the future 1100 MHz are used.
Prerequisites are a Ph.D. in Chemistry, Physics, Interdisciplinary Sciences, or related area, experience in solid-state NMR and NMR methodological development. Motivation to work in a multidisciplinary team. Starting date is upon mutual Agreement.
We look forward to receiving your application with motivation letter, CV and publication list. Please send it by e-mail to Beat Meier, .
If you are interested in working in our group, please write to Prof. Beat H. Meier and inquire about current possibilities. You should include in your application a short CV which explains your scientific background and (for postdocs) a publication list plus the names and addresses of two scientists who are willing to write a letter of reference for you.
You can either send the inquiry by e-mail or by regular mail or fax to us (Contact).